ABCDE criteria non optimal for pediatric melanoma diagnosis By Helen Albert, Senior medwireNews Reporter Conventional requirements for diagnosing melanoma may not be accurate in kids and adolescents, suggest results published in the Journal of the American Academy of Dermatology. A checklist of symptoms known as ABCDE – Asymmetry, Border irregularity, Color variegation, Diameter , Evolution – are commonly used to give an initial analysis of suspected melanoma. Nevertheless, while these criteria are largely accurate in the adult inhabitants, in today’s study, 60 percent of kids beneath the age of a decade and 40 percent of adolescents aged 11-19 years with melanoma or ambiguous melanocytic tumors didn’t present with these features.‘Provided the accumulating evidence of damage with rosiglitazone treatment and the lack of a distinct clinical benefit for the medication over pioglitazone, it is reasonable to question whether ongoing usage of rosiglitazone is certainly justified,’ they conclude. This scholarly study reinforces the message that thiazolidinediones should be avoided in heart failure patients, but the declare that pioglitazone is safer than rosiglitazone is not fully supported by the info, say two experts from the Universities of Bath and Surrey in an accompanying editorial. Although it may be tempting to move away from prescribing thiazolidinedione altogether, they write, long term follow-up data for newer items aren’t yet available. Considering that randomised trials are unlikely ever to provide the full picture, they claim that enhancements to health care databases coupled with well designed research like this one are essential for determining the full risk-benefit profile of medications.