Alexandre Loupy.

Alexandre Loupy, M.D., Ph la santé des hommes .D., Carmen Lefaucheur, M.D., Ph.D., Dewi Vernerey, M.P.H., Christof Prugger, M.D., Jean-Paul Duong van Huyen, M.D., Ph.D., Nuala Mooney, Ph.D., Caroline Suberbielle, M.D., Ph.D.D., Ph.D.D.D., Dany Anglicheau, M.D., Ph.D., Dominique Nochy, M.D., Dominique Charron, M.D., Ph.D., Jean-Philippe Empana, M.D., Ph.D., Michel Delahousse, M.D., Christophe Legendre, M.D., Denis Glotz, M.D., Ph.D., Gary S. Hill, M.D., Adriana Zeevi, Ph.D., and Xavier Jouven, M.D., Ph.D.: Complement-Binding Anti-HLA Antibodies and Kidney-Allograft Survival Despite significant advances in transplantation, the induced alloimmune response remains a major determinant of late kidney-allograft loss.1-3 In the United States and Europe, a large number of kidney transplants fail each year, and kidney-allograft failing is a major reason behind end-stage renal disease, leading to increased morbidity, mortality, and costs.4,5 Probably the most important developments in transplantation medicine has been the recognition that anti-HLA antibodies are destructive.6-10 Several studies over the past decade possess indicated that the alloimmune response, mediated by anti-HLA antibodies, takes on an integral role in the failure of kidney allografts; this idea has been extended to heart, lung, and composite tissue transplants.6 Although anti-HLA antibodies are believed to be harmful, there exists a wide spectral range of graft injury linked to these antibodies, ranging from no recognizable damage to florid rejection.11,12 Such a varied impact underscores the necessity to define distinct graft phenotypes and outcomes according to the presence or absence and features of donor-particular anti-HLA antibodies after transplantation.

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