.. Olivier Chosidow, M.D., Ph.D., Bruno Giraudeau, Ph.D., Jeremy Cottrell, M.S., Arezki Izri, M.D., Robert Hofmann, M.D., Ph.D., Stephen G. Mann, M.D., and Ian Burgess, Ph.D.: Oral Ivermectin versus Malathion Lotion for Difficult-to-Treat Head Lice Head lice are universal human parasites, affecting over 100 million people worldwide each year. In the developed world, children 3 to 11 years are likely to become affected. 1 Since the withdrawal in 2007 of the Cochrane overview of head-lice remedies,2 the only real review available is a systematic review3 released in 1995; it figured sufficient evidence of efficacy existed limited to the pyrethroid insecticide permethrin , which acquired a remedy rate with a lower 95 percent confidence limit greater than 90 percent.The RERE protein can be a transcriptional corepressor30 that’s highly expressed in lymphoid cells and is thought to regulate apoptosis.31 Perhaps the most interesting association that we found was between generalized vitiligo and a locus in chromosome 11q14.3, comprising 37 SNPs spanning the TYR gene area. The major allele of each SNP was associated with vitiligo. Three of these SNPs demonstrated genomewide significance; the strongest associations were with rs1847134 and rs1393350 . TYR encodes tyrosinase, a melanosomal enzyme that catalyzes the rate-limiting measures of melanin biosynthesis32 and constitutes a main autoantigen in generalized vitiligo.1,2 Finally, we detected a suggestive association signal at chromosome 14q12, involving 11 SNPs spanning the GZMB region, especially intragenic SNPs rs8192917 and rs2273844 .