ASO may correct striatal transcriptional abnormalities and improve behavioral complications in HD mice Findings from postmortem research of the brains of Huntington's Disease patients suggest that transcriptional dysregulation may be an early step in the pathogenesis of HD before symptoms appear. Other studies statement transcriptional alterations in the brains of some mouse types of HD click to follow . A new research has found transcriptional adjustments in mouse striatum which correlate with progressive electric motor and psychiatric deficits and, most of all, reports for the very first time, an antisense oligonucleotide may be used therapeutically to both right striatal transcriptional abnormalities and improve motor and behavioral problems.
‘The ATI Neurostimulation Program is normally well tolerated and can be used as often as needed, without daily limitations or stimulation-induced side effects’, said Prof. Dr. Rigmor Hoejland Jensen, Director of the Danish Headache Middle at Glostrup Medical center in Denmark. ‘Based on the results of the analysis, this new treatment choice offers a substantial improvement in quality of life to nearly all sufferers.’ The ATI Neurostimulation Program functions by stimulating the sphenopalatine ganglion , a nerve bundle deep in the facial skin that for years has been shown to play a significant role in cluster headache. ‘For years clinicians have targeted the SPG to relieve severe headache, primarily by applying anesthetics and other brokers to attain a nerve block,’ stated Prof.