Subjects with a number of variant alleles at either SNP had an increased geometric mean Lp lipoprotein level . Stepwise regression identified seven SNPs, including rs3798220 and rs10455872, that each had a significant association with Lp lipoprotein amounts lipoprotein by variance-components linkage analysis and estimated that about 74 percent of the full total variation in Lp lipoprotein levels was specific to the LPA locus.30 Consequently, it appears that the SNPs that were included in our study captured more than half the quantitative genetic variation encoded by LPA. Association between Lp Lipoprotein Level and Coronary Disease Variants at the LPA locus that were associated with increased results on Lp lipoprotein levels tended to be associated with increased effects on the risk of coronary disease .Copyright 2009 Advisory Board Organization and Kaiser Family Base. All rights reserved.. Alcohol related hospital admissions rise in Britain By Dr Ananya Mandal, MD Figures reveal that 1. These display that there is a 25 per cent increase in the amount of people admitted to hospital for reasons caused by drinking. The problem is more severe in some parts of the county than others with 3,114 people becoming admitted per 100,000 people in Liverpool, compared with 850 per 100,000 on the Isle of Wight.