This included all 418 patients who had slight reactions, all 116 individuals who got moderate reactions, and nine of the 11 sufferers who had severe reactions. Commonly used medications can be administered safely; nevertheless, treatment errors aren’t uncommon and in a few instances can lead to patient morbidity, stated Dr. Cohan. In our study, we found numerous instances where non-recommended treatment was supplied. These situations included the administration of oxygen by nasal cannula and at lower than recommended dosages, over-utilization of diphenhydramine , and the administration of greater than recommended dosages of epinephrine, as well as occasional confusion about which concentrations of epinephrine should be injected in which way .In the safety people , we compared the proportions of subjects with adverse events over the two vaccine groups and the placebo group, using Fisher’s exact test. Results Study Population Fifty-seven subjects composed the per-protocol population; two topics in the high-dosage vaccine group were excluded due to the existence of antibody against yellowish fever at baseline, and one subject in the placebo group was lost to follow up. The two seropositive subjects were most likely immunized during military services but were unaware that they had received the yellowish fever vaccine.