Related StoriesCornell biomedical engineers develop 'super natural killer cells' to destroy malignancy cells in lymph nodesMeat-rich diet may increase kidney cancer riskNew findings reveal association between colorectal malignancy and melanoma drug treatment Results on ‘unwanted effects’ are uncertain Most data on ‘side effects’ offered by the pharmaceutical firm were also not analysed appropriately, and may not be used therefore. This was true for the entire rate of adverse occasions and for critical adverse events, as well as for the precise adverse events ‘fractures’ and ‘fluid retention/oedema’. The main reason these data cannot be used was that the difference in treatment duration in both study hands was not taken into consideration appropriately by the manufacturer in the analyses.Information on the hypothesis, the decision rules for the rejection of the null hypotheses, decision guidelines for early discontinuation of the analysis in a cohort because of efficacy or futility, and statistical methods are provided in Supplementary Appendix 1. Results Patients A complete of 41 consecutive patients were enrolled in the study and treated during the period from September 2013 through January 2015 . Recruitment included individuals in search of a scientific trial option who were recognized to possess tumors with mismatch-restoration defects or who had tumors of unfamiliar status who were then tested.e., greater than the cutoff specified in the inclusion requirements).